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Guggul |
Guggul
Caplet is a standardized
preparation extracted from Commiphora
mukul, the resin of Guggul tree.
The active portion of the plant
is the gum resin, which contains
guggulsterone. Guggul is known
to lower cholesterol and triglycerides,
while maintain or improve the
HDL to LDL ratio. Its benenfits
as a weight-loss and fat burning
agent have been well researched
and documented in several studies. |
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Research
Update
The effects of the administration
of 50 mg of guggulipid or placebo
capsules twice daily for 24 weeks
were compared as adjuncts to a
fruit- and vegetable-enriched
prudent diet in the management
of 61 patients with hypercholesterolemia
(31 in the guggulipid group and
30 in the placebo group) in a
randomized, double-blind fashion.
Guggulipid decreased the total
cholesterol level by 11.7%, the
low density lipoprotein cholesterol
(LDL) by 12.5%, triglycerides
by 12.0%, and the total cholesterol/high
density lipoprotein (HDL) cholesterol
ratio by 11.1% from the postdiet
levels, whereas the levels were
unchanged in the placebo group.
The HDL cholesterol level showed
no changes in the two groups.
The lipid peroxides, indicating
oxidative stress, declined 33.3%
in the guggulipid group without
any decrease in the placebo group.
The compliance of patients was
greater than 96%. The combined
effect of diet and guggulipid
at 36 weeks was as great as the
reported lipid-lowering effect
of modern drugs. After a washout
period of another 12 weeks, changes
in blood lipoproteins were reversed
in the guggulipid group without
such changes in the placebo group.
Additional
benefits
The effectiveness of Commiphora
mukul (guggul) for osteoarthritis
of the knee: an outcomes study.
The scientists have conducted
both preclinical and clinical
investigations of guggul for
reduction of pain, stiffness,
and improved function, and to
determine tolerability in older
patients with a diagnosis of
OA of the knee.
CONCLUSIONS:
Overall data indicate significant
improvement with guggul for
participants during the trial
in both scales and objective
measures used for assessment
purposes. There were no side
effects reported during the
trial. Guggul appears to be
a relatively safe and effective
supplement to reduce symptoms
of OA.
In addition Guggul is also helpful
even in protecting against ailments
such as common cold, and various
skin, dental and ophthalmic
infections. It relaxes the muscles,
which helps relieve menstrual
pain.
Interactions:
Guggul can be problematic for
people being treated for thyroid
conditions. Since guggul stimulates
production of thyroid hormone,
it may alter the dosage requirements
for thyroid replacement medication.
It can also reduce the availability
and effectiveness of the heart
medications propranolol (Inderal)
and diltiazem (Cardizem). Patients
should consult a health care
practitioner before taking guggul
along with any other herbs or
medications
Side
Effects
Side effects of guggulipid were
headache, mild nausea, eructation,
and hiccup in a few patients.
Supplement
Facts
Serving Size 1 Vegetarian Caplet
Amount Per Caplet
Guggul extract - 300 mg. Suitable
for vegetarians.
Suggested
Use
As an herbal dietary supplement,
take 1 Guggul Caplet 1 to 3 times
daily.
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